pentobarbital will decrease the level or effect of losartan samhälle affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.
pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stark CYP3A4 inducers can reduce panobinostat levels ort ~70% and lead to treatment failure.
pentobarbital increases toxicity of ifosfamide samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Bildskärm. CYP3A4 inducers may increase the metabolism of ifosfamide to its active alkylating metabolites.
pentobarbital will decrease the level or effect of fostemsavir samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
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pentobarbital decreases levels of toremifene ort affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Bildskärm. CYP3A4 inducers increase rate of toremifene metabolism, lowering the steady-state concentration in serum.
pentobarbital will decrease the level or effect of fentanyl transdermal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Datorskärm Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to a decrease in fentanyl plasma concentrations, lack of efficacy or, possibly, development of a withdrawal syndrome in a patient who has developed physical Pentobarbitalnatrium oral vätska till salu online dependence to fentanyl.
buprenorphine subdermal implant and pentobarbital both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate
pentobarbital will decrease the level or effect of zaleplon by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
pentobarbital will decrease the level or effect of mestranol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Bildskärm.
pentobarbital will decrease the level or effect of larotrectinib ort affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will decrease the level or effect of fludrocortisone ort affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Datorskärm.
pentobarbital will decrease the level or effect of quinidine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Bildskärm.
The barbiturates are nonselective viktig nervous ordna depressants which are primarily used as sedative hypnotics knipa also anticonvulsants in subhypnotic doses. The barbiturates and their sodium salts are subject to control mirakel the Federal Controlled Substances Act (See “Drug Abuse and Dependence” section). The sodium salts of amobarbital, pentobarbital, phenobarbital, knipa secobarbital are available as sterile parenteral solutions. Barbiturates are substituted pyrimidine derivatives in which the basic structure common to these drugs is barbituric acid, a substance which has no central nervous system (CNS) activity.