pentobarbital will decrease the level or effect of losartan samhälle affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stark CYP3A4 inducers can reduce panobinostat levels ort ~70% and lead to treatment